McGuire's journey began in 1946 when he led St. John's University to the NCAA Championship, earning himself the Most Outstanding Player award. His exceptional ball-handling skills, deceptive footwork, and pinpoint passing made him a magician on the court, weaving through defenders with remarkable agility. He earned the nickname "Tiny Terror" not for his size, but for the terror he inflicted on opposing teams.

After a successful college career, McGuire entered the NBA in 1949, joining the New York Knicks. He quickly established himself as a scoring machine, averaging a career-high 22.1 points per game in his rookie season. His playmaking abilities also blossomed, leading the league in assists three times throughout his career.

McGuire's impact went beyond individual accolades. He became a key player in the Knicks' rise to prominence, helping them reach the NBA Finals in 1951 and 1952. He was also instrumental in the formation of the NBA Players Association, advocating for the rights and welfare of his fellow players.