The journey to find the most substantial Major League Baseball players that wore the number 25 on their uniforms starts by looking at who the Baseball Hall of Fame has in their hallowed halls. Enshrined number ones of professional baseball are:
- George Wright
- Jim O'Rourke
- Kiki Cuyler
- Al Kaline
- Harmon Killebrew
- Enos Slaughter
- Hoyt Wilhelm
- Larry Doby
- George Brett
- Orlando Cepeda
- Rickey Henderson
- Frank Thomas
- Mike Piazza
Another telling clue to find the best is to see who has the MLB number 25 retired by their respective teams. This list of retired number 25s includes:
- José Cruz had the Houston Astros put away his number 25 uniform on October 3, 1992
- Barry Bonds and the San Francisco Giants celebrated the retirement of his Jersey 25 on August 11, 2018
- Jim Thome's Number 25 was put in a place of honor by the Cleveland Indians back on August 18, 2018