The journey to find the most substantial Major League Baseball players that wore the number 22 on their uniforms starts by looking at who the Baseball Hall of Fame has in their hallowed halls. Enshrined number ones of professional baseball are:
- Paul Waner
- Dizzy Dean
- Sam Rice
- Red Ruffing
- Satchel Paige
- Lefty Gomez
- Jim Palmer
- Gaylord Perry
- Mike Schmidt
- Tony Gwynn
- Rickey Henderson
- Oscar Charleston
- Whitey Herzog
- Bert Blyleven
- Tony La Russa
- Randy Johnson
Another telling clue to find the best is to see who has the MLB number 22 retired by their respective teams. This list of retired number 10s includes:
- Jim Palmer had his number 22 retired by his former club the Baltimore Orioles on September 1, 1985