Quackenbush's journey began with the Detroit Red Wings in 1949. Though not drafted high, his dedication and defensive prowess earned him a spot on the team. He quickly established himself as a reliable stay-at-home defenseman known for his physicality, strong positioning, and ability to shut down opposing forwards. Despite not racking up gaudy offensive numbers, Quackenbush's defensive contributions were crucial to the Red Wings' success, helping them reach the Stanley Cup Finals in 1950 and 1952.

In 1955, Quackenbush was traded to the Boston Bruins, where he continued to excel defensively. He formed a formidable partnership with fellow defenseman Clyde Sutherland, earning the nickname "The Chinese Wall" for their ability to block shots and frustrate opponents. Together, they anchored a strong Bruins defense that helped the team reach the Stanley Cup Finals in 1957 and 1967.

Throughout his career, Quackenbush earned a reputation as a leader and a true team player. He was known for his work ethic, dedication to conditioning, and his willingness to sacrifice personal glory for the good of the team. While he never won a Stanley Cup, his contributions were instrumental in the success of both the Red Wings and the Bruins, making him an unsung hero in the eyes of many hockey fans and analysts.

Beyond his on-ice contributions, Quackenbush is also remembered for his sportsmanship and character. He rarely took penalties and was known for his clean style of play, earning him the respect of teammates, opponents, and fans alike.

After retiring in 1970, Quackenbush remained involved in the sport as a coach and broadcaster. His legacy lives on as a testament to the importance of defensive excellence and the vital role that players like him play in team success. Bill Quackenbush's career may not be defined by individual accolades, but his dedication, work ethic, and defensive prowess solidify his place as a true icon in the history of hockey.